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KMID : 0359320160560040205
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Korean Journal of Veterinary Research
2016 Volume.56 No. 4 p.205 ~ p.208
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Serum serotonin concentration in lean and obese dogs with myxomatous mitral valve disease
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Kim Kyu-Tae
Park Hee-Myung
Hyun Chang-Baig
Seo Kyoung-Won
Song Kun-Ho
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Abstract
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The aim of the present study is to investigate the potential influence of obesity as a factor in 5hydroxytryptamine (5-HT) concentration in myxomatous mitral valve disease (MMVD) dogs. Fifty-five client-owned dogs were enrolled in a randomized trial. Dogs were classified by echocardiography into healthy (control), mild, and moderate to severe MMVD groups. Each group was subclassified by using a 9-point body condition score (BCS); lean (BCS 5?6/9) and obese groups (BCS 7.5?9/9). Dogs with moderate to severe MMVD had lower serotonin (5HT) concentrations than the control group (p = 0.03). Dogs with moderate to severe MMVD (p = 0.017) had lower serum 5-HT concentrations than the control group in the obese group (BCS 7.5?9/9). Significant difference was found between the lean and obese groups (p = 0.015) which are not consider severe in the MMVD group. These results suggested that 5-HT concentration was decreased with the increasing severity of MMVD, and obesity might be taken into consideration when interpreting the serotonin concentration in MMVD dogs.
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KEYWORD
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5-HT concentration, body condition score, dogs, myxomatous mitral valve disease, obesity
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